Hydroxyl Ethyl Cellulose HHX and Polymethyl Methacrylate Based Site Specific Floating Delivery of Prochlorperazine Maleate

Synthesis and thermal characterization of polymethyl methacrylate

PMMA with molecular mass (PMMA Mw: 1.2×105) was synthesized through AIBN initiated free radical polymerization methyl methacrylate at 100 ± 1°C.The synthesized polymer was characterized through GPC coupled with RI detector in presence of THF as mobile phase at 1.0 mL/ min and simultaneous TG-DTA-DTG in nitrogen. TG data were used to investigate the non-isothermal kinetics of solid-state decompo...

Formulation Design of Novel Fast Disintegrating Tablets of Prochlorperazine Maleate

In the present work, fast disintegrating tablets of prochlorperazine maleate were prepared with a view to enhance patient compliance by direct compression method. Three superdisintegrants i.e., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with MCC (Avicel, PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepa...

Second Generation Polymethyl-methacrylate- Sorbitol Capsules – Development and Elution Studies of a Local Antibiotic Delivery Vehicle

Design and in vitro Evaluation of Gastroretentive Floating Drug Delivery System of Rosigilitazone Maleate

Rosigilitazone maleate is an anti-diabetic agent is used in the management of Type-II diabetes mellitus. The present investigation concerns the development of the sustained release floating matrix tablets which are designed to exhibit a prolonged gastric residence time and controlling the drug release from the dosage form. This system is useful particularly for achieving controlled plasma level...

Salvage of Infected Nasal Reconstruction with a Polymethyl Methacrylate Spacer

Total nasal reconstruction is a challenging multistage procedure. Infections can destroy the cartilage framework and seriously compromise the result. The use of polymethyl methacrylate with antibiotics as a spacer has been described in the treatment of skeletal infections. Using this same principle, the use of a polymethyl methacrylate with antibiotics spacer for an infected nasal reconstructio...